Platelet-Rich Fibrin (PRF)
Platelet-Rich Fibrin (PRF) – is an advanced, natural regenerative treatment that uses your body’s own healing power to revitalise the skin, restore volume, and support long-term skin health. PRF is an evolution of PRP (Platelet-Rich Plasma) that provides a richer concentration of platelets, white blood cells, fibrin, growth factors and exosomes – all without any additives or anticoagulants.
100% Natural Regeneration
PRF is derived from a simple blood draw, taken at the time of your appointment. The blood is gently spun in a special centrifuge to separate the key regenerative components. Because the collection tubes are additive-free and contain no anticoagulants, the PRF forms a natural fibrin matrix – a soft scaffold that creates a lattice-like structure. This structure gradually traps and releases growth factors and exosomes into the skin over several days, enhancing your body’s own collagen production and tissue repair systems.
What to Expect from PRF
Patients can expect improvement in:
- Skin texture and tone
- Fine lines and wrinkles
- Under-eye hollowness and dark circles
- Smile lines and upper lip lines
- Skin firmness and elasticity
- Overall radiance and hydration
The treatment is especially popular for tear trough rejuvenation, one of the most delicate areas where PRF’s natural and slow-release effect truly shines.
Powerful Growth Factors and Exosomes in PRF
Your PRF is rich in a potent mix of healing molecules, including:
- PDGF (Platelet-Derived Growth Factor) – stimulates cell growth and new blood vessel formation
- TGF-β (Transforming Growth Factor Beta) – supports collagen synthesis and tissue repair
- VEGF (Vascular Endothelial Growth Factor) – promotes new capillary growth for oxygen-rich skin
- IGF (Insulin-like Growth Factor) – encourages cellular turnover and healing
- EGF (Epidermal Growth Factor) – accelerates skin regeneration
- FGF (Fibroblast Growth Factor) – boosts fibroblast activity and skin thickness
- Exosomes – nanoscale messengers that carry genetic material and proteins to stimulate collagen and elastin production
Together, these bioactive components drive the rejuvenation process from the inside out.
How PRF Is Applied
At Self Aesthetics, PRF is administered in two ways:
- Direct Injection – Small volumes of PRF are carefully injected via a cannula into target areas such as smile lines, upper lip lines, and under the eyes to restore volume and soften lines.
- Skin Needling with PRF Infusion – We combine PRF with a medical-grade skin needling treatment to deliver growth factors deep into the dermis. This dual delivery method ensures optimal skin regeneration.
Comfortable and Safe
Because PRF is completely natural and derived from your own blood, there’s minimal risk of reaction. The absence of additives in the collection tubes also makes the treatment much more comfortable than many synthetic alternatives.
Why Maintenance Matters
Regenerative treatments like PRF work by stimulating your skin’s own healing response. While you’ll notice improvements after your first session, the true benefits build over time. A series of treatments spaced 4–6 weeks apart is recommended to maximise collagen induction and prolong results. Maintenance treatments every 4–6 months help sustain your youthful glow and skin health over time.
Both PRP and PRF offer incredible regenerative benefits. PRP is ideal when you want fast-acting results and an immediate boost in skin texture and hydration. PRF, on the other hand, offers a slow release of growth factors due to its fibrin lattice structure, making it more suited to volume restoration and longer-lasting rejuvenation, particularly in delicate areas like the under eyes.
At Self Aesthetics, your treatment plan is customised based on your goals and skin condition – sometimes combining both PRP and PRF for maximum effect.